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At the molecular level, spaceflight-specific gene expression changes occurred in stress response element (STRE) genes (e.g., SSA4, YIL052C, YST2) with transcription regulated by Sfp1 (involved in the TOR pathway) and Msn4 105 , and certain components of ribosome biogenesis (controlled by Sfp1) and the proteasome were downregulated in microgravity 102

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Research indicates that surface treatment of implants with appropriate concentration of NAC can mitigate oxidative stress and reduce the upregulated expression of pro-inflammatory cytokines induced by LPS and hyperlipidemia