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However, these effects are prevented in fasted animals due to a reduction in the increment of the glomerular transcapillary hydrostatic pressure.15 Additionally, a protein-rich diet also stimulates VEGF signaling, which promotes glomerular hypertrophy.84 In contrast, low-protein diet leads to reduced serum GH and IGF-1 levels in rats, which could help preventing glomerulosclerosis.85 It is important to note that appetite-regulating endocrine factors, such as leptin, a hormone that induces satiation, may be linked to IGF-1 production in renal patients