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--- #Pharmacology #NSAIDs #Diclofenac #Aceclofenac #MedicalEducation #Pharmacy To view or add a comment, sign in Key FDA approval (April 2026)🔥 🔥 ~~~~~~~~~~~~~~~~~~~~~~~~~~ 🔵 FDA approved orforglipron (Foundayo) – first oral non-peptide GLP-1 receptor agonist 🔵 Indication: chronic weight management in adults with obesity OR overweight + ≥1 comorbidity 🔵 Must be combined with lifestyle intervention (diet + physical activity) 🟡 Mechanism & unique features 🟡 GLP-1 receptor partial agonist (oral tablet) 🟡 Once daily dosing 🟡 Unlike semaglutide oral → does NOT require fasting administration 🟡 Represents shift toward easier adherence vs injectable GLP-1 agents 🟢 Dosing strategy (stepwise escalation) 🟢 Start: 0.8 mg daily 🟢 After ≥30 days → 2.5 mg 🟢 After ≥30 days → 5.5 mg 🟢 Further escalation (each ≥30 days based on response/tolerance): 🟢 9 mg → 14.5 mg → 17.2 mg 🟣 Efficacy (clinical trials) 🟣 Two RCTs, 72 weeks duration 🟣 Statistically significant and clinically meaningful weight reduction vs placebo 🟣 Benefit seen when combined with lifestyle modification 🔵 Common adverse effects (class-consistent) 🔵 Nausea, vomiting, diarrhea, constipation 🔵 Dyspepsia, abdominal pain, GERD, bloating 🔵 Fatigue, headache 🔵 Hair loss reported 🟡 Serious warnings / precautions 🟡 Pancreatitis 🟡 Severe GI reactions 🟡 Acute kidney injury (volume depletion) 🟡 Hypoglycemia (especially with other agents) 🟡 Diabetic retinopathy worsening 🟡 Gallbladder disease 🟡 Aspiration risk during anesthesia 🟢 Contraindications (critical endocrine relevance) 🟢 Boxed warning: thyroid C-cell tumors 🟢 Avoid in: 🟢 Medullary thyroid carcinoma (personal/family history) 🟢 MEN2 (Multiple Endocrine Neoplasia type 2) 🟣 Important clinical points (high-yield) 🟣 Do NOT combine with another GLP-1 receptor agonist 🟣 First oral GLP-1 option without strict administration conditions → major adherence advantage 🟣 Likely strong competitor to semaglutide/tirzepatide in obesity care 🟣 Represents evolution toward non-injectable incretin-based therapy 🔵 Big picture (practice-changing insight) 🔵 This approval is not just a new drug → it signals a shift: 🔵 Oral incretin therapy becoming mainstream 🔵 Lower barrier for patients refusing injections 🔵 Potential earlier use in obesity treatment pathways 🔵 May significantly expand real-world uptake of GLP-1 therapy To view or add a comment, sign in 45,136 followers