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However, despite strong epidemiological and mechanistic evidence linking obesity-induced OS to endometrial diseases, clinical direct evidence remains insufficient and its clinical application is relatively limited

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The hormone dependent interaction of the NH 2 -terminal domain with the ligand binding domain can play a role in stabilization of the androgen receptor dimer complex and in stabilization of the ligand receptor complex by slowing the rate of ligand dissociation and decreasing receptor degradation (116, 117)