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In the CCl4-induced liver injury model, Schisandrin B was shown to activate the Nrf2/Antioxidant Response Element (ARE) signaling pathway, upregulate the expression of antioxidant genes, and enhance cellular antioxidant capacity, ultimately reducing hepatocyte damage (Yuan et al., 2018)
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The clearance allows it to move into human clinical trials, with the first study focused primarily on safety
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