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--- #Pharmacology #NSAIDs #Diclofenac #Aceclofenac #MedicalEducation #Pharmacy To view or add a comment, sign in 💊 Diclofenac vs Aceclofenac – Complete Clinical Comparison 🔹 Class: Both are NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) --- 🔹 Mechanism of Action: • Diclofenac: Non-selective COX-1 & COX-2 inhibitor (more potent, higher GI risk) • Aceclofenac: Preferential COX-2 inhibitor (better tolerated, less gastric irritation) --- 🔹 Adult Dose: 👉 Diclofenac • Oral: 50 mg 2–3 times daily • Max Dose: 150 mg/day • Injection (IM/IV): 75 mg once or twice daily 👉 Aceclofenac • Oral: 100 mg twice daily • Max Dose: 200 mg/day --- 🔹 Pediatric Dose: 👉 Diclofenac • 1–3 mg/kg/day in divided doses • Common: 1 mg/kg/dose 2–3 times daily 👉 Aceclofenac • Not routinely recommended in children (limited safety data) --- 🔹 Dose per kg: • Diclofenac: 1 mg/kg per dose (max as per adult limits) • Aceclofenac: No standard per kg dose (avoid in pediatrics) --- 🔹 Pregnancy Use: • Both drugs ❌ Contraindicated in 3rd trimester (risk of premature ductus arteriosus closure) • Use in 1st & 2nd trimester only if clearly needed • Prefer safer alternatives like Paracetamol --- 🔹 Effects: 👉 Diclofenac • Strong analgesic & anti-inflammatory • Fast acting • Higher GI irritation & ulcer risk 👉 Aceclofenac • Moderate analgesic effect • Better GI tolerance • Preferred for chronic conditions --- 🔹 Side Effects: Common (Both): • Nausea, vomiting • Gastric irritation • Headache, dizziness Serious: • GI bleeding (more in Diclofenac) • Renal toxicity • Cardiovascular risk (long-term use) --- 🔹 Contraindications: • Peptic ulcer disease • Severe renal/hepatic impairment • NSAID allergy • Late pregnancy --- 🔹 Available Dosage Forms: Diclofenac: • Tablets (25, 50 mg) • Injection (75 mg/ml) • Gel / topical • Suppository Aceclofenac: • Tablets (100 mg) • Combination tablets (with paracetamol, serratiopeptidase) --- 🔹 Clinical Insight: Diclofenac is more potent but has higher side effect risk