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AA, an unsaturated fatty acid, released from the cell membrane in response to various cytokines, peptides and growth factors [58], can be metabolized by COX, LOX, and cytochrome P450 (CYP450) monooxygenases to synthesize bioactive inflammatory mediators such as prostaglandins (PGs), leukotrienes (LTs), epoxyeicosatrienenoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs) [59] (Fig

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