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Select a Community MB 1 Preclinical Medical Students MB 2/3 Clinical Medical Students ORTHO Orthopaedic Surgery About Bullet Health Images Thioamides propylthiouracil (PTU) methimazole Mechanism inhibit thyroid hormone synthesis by blocking peroxidase-catalyzed reactions iodination of tyrosine residues of thyroglobulin coupling of DIT and MIT propylthiouracil ↓ peripheral conversion of T 4 to T 3 Clinical use HYPERthyroidism skin rash aplastic anemia hepatotoxicity (PTU) PTU not used first line in non-pregnant adults and children for this reason Pregnancy use PTU in the first trimester methimazole crosses the placenta and enters breast milk (may be teratogenic) Thyroid hormones Drugs levothyroxine synthetic T 4 (thyroxine) triiodothyronine T 3 Mechanism replaces endogenous thyroid hormones Clinical use HYPOthyroidism myxedema Toxicity thyrotoxicosis heat intolerance tachycardia dyspnea ↑ appetite tremors arrhythmias Create a free account or log in to see the cards.

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Both LF and LYZ are very low in bovine milk, in which IGs form the main defense against microbes [53]