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The gut-brain axis is complex, and altering gut hormone signaling can have downstream effects on neurotransmitter systems that influence mood and emotional regulation
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Figure 1 The MTb natural metabolite Pht was found to activate CYP1B1 and AHRR transcription in THP-1 cells in an AhR-dependent manner (Moura-Alves et al., CYP1B1 and AHRR transcription were promoted by 2.2- and 1.9-fold with the addition of 10 μM Pht in THP-1 human monocytes compared to control (DMSO only), respectively (Figures 1C,D)
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