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567 Endocrine & Diabetes The Effect of Associated Autoimmune Disease on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus Simona Cainap 1 , Claudia Bolba 1 , Madalina Ursu 1 , Adriana Bungardi 1 , Georgia Tita 1 , Bogdan Lucian 2 1 Second Departament of Pediatrics, University of Medicine and Pharmacy "Iuliu Hatieganu", Romania 2 Departament of Pediatrics, Emergency County Hospital "Dr Constantin Opris", Romania Diabetes mellitus type 1(T1DM) is one of the most common chronic diseases in childhood, is caused by insulin deficiency resulting from the destruction of insulin-producing pancreatic beta cells
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Additionally, the knockdown of YY1 decreases the protective effects of resveratrol (an agonist of SIRT1) on EMT and fibrosis in db/db mice (Du et al., 2021)
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