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Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial Could overt diabetes be triggered by abuse of selective androgen receptor modulators and growth hormone secretagogues

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What they found: Mean GH levels rose 2 to 10-fold depending on the dose IGF-1 rose 1.5 to 3-fold and remained elevated for several days The profile was well tolerated in the tested dose range Why it matters: This is one of the few human studies in this field

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