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To our knowledge, this is the first study to evaluate the susceptibly of substrain differences in two widely used strains of C57BL6 mice in response to cpz-toxin by longitudinal brain imaging and histopathology Studying innate immune biology in the brain can be impacted by technical variables as illustrated by recent publications, identifying stronger protocol than biology dependence of transcriptomic profiles of microglia (Gosselin et al., 2017, Krasemann et al., 2017, Dubbelaar et al., 2018)
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