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Discovery, optimization, and evaluation of quinazolinone derivatives with novel linkers as orally efficacious phosphoinositide-3-kinase delta inhibitors for treatment of inflammatory diseases
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found that activating transcription factor 4 (ATF4) binds to the ASNS gene promoter through Zinc Finger and BTB domain-containing protein 1 (ZBTB1) to promote ASNS transcription in drug-resistant T-cell leukemia
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