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Studies indicate that iNOS induction generally requires at least 2 h in the rat forebrain after ischemia [111], 3 h in rat cardiomyocytes after LPS/IL-1β/TNF-α/or IFN-γ stimulation [112], 4 h in the rat choroid plexus after IL-1β [113], and 72 h in rat brain astrocytes following LPS induction [114]
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