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Nowadays, an increasing number of studies indicates that early administration of NAC may reduce markers of oxidative stress and alleviate inflammation in animal models of acute lung injury (ALI) and in patients suffering from distinct forms of acute respiratory distress syndrome (ARDS) or pulmonary infections including community-acquired pneumonia or Coronavirus Disease (COVID)-19

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In this article, we will focus on the currently known mechanisms of action of modafinil, their involvement in the therapeutic efficacy of its approved clinical uses, and its suggested potential (off-label) use for neuropsychiatric disorders