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In vivo studies showed that chronic exposure to PQ induced significant impairments in balance and vertical limb movements through prolonged latency of T25cm, T-turn, and T-total in the pole test (41, 49, 50)
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Nuclear NAD + is generated by nuclear NMNAT1 and is largely utilized by PARPs for DNA damage response and nuclear sirtuins such as SIRT1, SIRT6 or SIRT7 for epigenetic deacetylation 82,86
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