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Shungu then applied for a pilot grant (R21) which found that 1800 mg NAC supplementation returned glutathione, lactate, and oxidative stress levels to normal and helped with symptoms in ME/CFS

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In contrast, some concerns were frequently identified in the randomization process (four trials with incompletely described sequence generation and/or allocation concealment) and in selection of the reported result, as none of the trials had a publicly available preregistered protocol or analysis plan