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Small randomized trials have begun, including in eye disease and in older adults with frailty, but none has yet demonstrated a convincing clinical benefit for an aging-related condition

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Results Caffeine Does Not Have Antioxidant Activity in vitro but Promotes SIRT3 Activity Caffeine is a highly stable alkaloid compound that is not easily oxidized, with methyl groups at the 1, 3, and 7 positions of the purine ring structure (Figure 1A)