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10(1):RA5-14 Drugs: Cimetidine & Grapefruit Juice Mechanism of Action: P-glycoprotein inhibitors (& inhibitors of cyt-P450) Pharmacokinetics: Cells in the intestinal tract contain a P-glycoprotein that acts as a reverse transporter which actively pumps drugs out of the cells in the gut wall back into the gut lumen

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