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To explore the role of DDX3X in lung cancer, we initially bred Ddx3x fl/ fl mice to lox-stop-lox- Kras G12D mice to generate Kras G12D ;Ddx3x fl/fl and Kras G12D ;Ddx3x fl/y offspring
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Androgen signaling as evidenced in castration therapy studies, manipulates this immunosuppressive network by inhibiting arginine metabolism via two synergistic pathways: 1) Myeloid-derived suppressor cells (e.g., CD11b + cells) overexpressing ARG1 deplete extracellular L-arginine, crippling T-cell function through CD3ζ chain downregulation, impaired antigen recognition, and dual activation of the GCN2-eIF2α stress pathway with concurrent mTOR suppression (185–187)
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