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Administration of bumetanide, an NKCC1 chloride importer antagonist, can restore the GABA developmental shifts eliminated by Mecp2 mutations and reduce the increased glutamatergic/GABAergic PSC ratio (77)
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AMPK is activated by low cellular energy (an increased AMP/ATP ratio) or low glucose availability (such as a low fructose-1,6-bisphosphate level) 29,30 (Figure 2)
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