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Radiotherapy has also been shown to upregulate interleukin-1 receptor-associated kinase 1 (IRAK1) via activation of stimulator of interferon genes (STING) signaling
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Finally, our studies also underscore the value of in vivo pre-clinical models in capturing physiologically relevant metabolic dependencies that may be missed in vitro and pave the way for development of FSP1 inhibitors for clinical testing in patients with lung cancer
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