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doi: 10.1016/j.neulet.2018.09.031

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How AOD-9604 Works (in Brief) AOD-9604 was engineered from the C-terminal segment of human growth hormone (amino acids 177–191) — the portion thought to influence fat metabolism.¹ ² In preclinical models, this fragment supported fat oxidation and lipid mobilization without the broader hormonal effects of full-length hGH.³ ⁴ Because it does not activate the traditional hGH receptor, its fat-metabolism effects are considered indirect and receptor-independent.² Discovery & Research Milestones Originally developed in the 1990s as a potential anti-obesity drug