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Accordingly, we detected a mild phosphorylation of p53 in ∆ ADH5 HCT116 cells exposed to FA (Fig
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The potentially more-harm-than-benefit effect of Nrf2 on cancer was recognized from the observations that some tumors have persistently elevated expression of ARE genes, indicating that cancer cells hijack the protective power of Nrf2 to increase resistance to oxidants and cancer-killing agents
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