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As a triple agonist targeting GLP-1, GIP, and glucagon receptors, retatrutide offers a mechanism uniquely suited to bodybuilding goals: GLP-1 receptor: Reduces appetite and food intake — essential for getting slim during a cutting phase GIP receptor: May support lean mass preservation and nutrient partitioning — relevant for muscle building goals Glucagon receptor: Directly increases metabolic rate and fat oxidation — a mechanism no GHRP bodybuilding peptide could match Phase 2 trial data published in The Lancet showed up to 24.2% body weight reduction with retatrutide — the highest of any peptide injection studied to date