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In parallel, microglia mediate the engulfment of supernumerary synapses during postnatal development, revealing an immune [microglia-specific complement receptor 3 (CR3)/C3 signaling]-driven mechanism for sculpting neural circuits (Stevens et al., 2007
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Higher resting cerebrovascular tone may occur due to endothelial dysfunction (Willie et al., 2014), as seen in cardiovascular disease (Jay Widmer and Lerman, 2014
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