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Histidine tag has many advantages over other affinity tags such as small size, high affinity for binding to IMAC resins (Immobilized metal affinity chromatography) and allows one step purification of recombinant protein
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For example, there are reports of reorganization of the motor and somatosensory cortex in upper extremity amputees with phantom pain [ 145 , 146 , 147 , 148 ]
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