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This accumulation supports the biosynthesis of nonessential amino acids (NEAAs) and stimulates the activation of mechanistic target of rapamycin complex 1 (mTORC1), which in turn promotes tumor growth (Dai et al., 2022)

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In 2022, it was reported that the enzyme was not able to bind with LOX or to block lipoxygenase-catalyzed biosynthesis of specialized pro-resolving mediators [60]