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Pediatric patients and those with delayed presentations of clinical cholestasis of undetermined etiology, or a family history of cholestatic disease, should be considered for NGS or WES genetic testing

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Indeed, extensive therapeutic use of flavonoids and similar polyphenolic compounds post-TBI have proven this to be true, with these compounds serving to remedy many TBI-induced maladies such as edema, neuroinflammation, cognitive and neuronal functions, cell survival, oxidative stress, and cellular energy homeostasis [60-63]

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