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The heart is thus endowed with impressive ATP production capacities depending on tightly regulated metabolic processes, the alterations of which have extensively been described in HF settings since the 1980s [3]
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In all the five studies, an oral (Delpre’s study via sublingual route) dose of 1000 μg vitamin B 12 was used with the exception of Kuzminski’s study, whereby a higher dose of 2000 μg was used
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