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In colorectal cancer, the adenoma-carcinoma pathway is one of the most common molecular pathways, leading to the formation of the tumor itself and altering the proliferation pattern of epithelial cells of the colon, forming aberrant crypts and/or aberrant crypt foci (ACF), which are called pre-neoplastic lesions of CRC [53] and are used as biomarkers of the initial stage of the disease [9]
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