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Ultimately, it was revealed that cholinergic fibers are present within the subchondral bone of individuals with OA, and the release of acetylcholine (Ach) triggered by vagus nerve stimulation plays a prominent role in combating inflammation across various diseases while also providing pain relief
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Glutathionylated proteins identified include cytoskeletal proteins, transcription factors, signaling proteins, ras and heat shock proteins, ion channels, calcium pumps and binding proteins, and glycolysis enzymes [80]
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