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HMGB1 activates the MyD88/TRIF-dependent NF-κB pathway by binding to the RAGE and TLR2/4 receptors, which promotes the synthesis and release of core inflammatory mediators such as IL-6 and TNF-α by macrophages (185): IL-6 activates and maintains the inflammatory response, promotes T cell proliferation and differentiation, and enhances the immune response
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