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fragmentary and historical data available DSIP and other sleep factors – research item: In the landscape of endogenous sleep regulators, DSIP occupies a position different from better characterized molecules: Adenosine — works through defined A1/A2A receptors, with a clear mechanism for increasing sleep pressure Prostaglandin D2 — acts through the DP receptor, with a documented somnogenic pathway Somnogenic cytokines (IL-1, TNF) — act through their own cytokine receptors, linking sleep with the immune response DSIP — there is no established receptor

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