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The nanocomposite architecture ensures sustained drug release, prolonged half-life, and enhanced tissue penetration, collectively mitigating gouty inflammation and preventing urate crystal-induced nephropathy ( Additionally, PEG–drug conjugates are prevalent functionalized carriers where PEG modifies therapeutic agents (e.g., uricase) to improve pharmacokinetics and reduce immunogenicity (Ozer et al., 2022)

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This method has been shown to be highly effective, preserving stem cell viability and their ability to differentiate into functional TM cells (266)