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Then, H 2 O 2 gets converted to hydroxyl radical (OH - ), or associated metal related reactive species, in the existence of increased transition metal (Fe 2+ , Cu + )·H 2 O 2 traverse cell membranes easily and gets converted into H 2 O by catalase (CAT) (the inner mitochondrial membrane and peroxisomes possess CAT, which is a heme protein) or by (selenium-containing) glutathione peroxidase (GPX

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