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by reacting in self-defense, neurons produce antioxidants in increased quantities, including the modified form of the Aβ protein, which thus becomes an antioxidant pro-oxidant, amplifying oxidative disasters by initiating chain reactions ( Mutations of the superoxide dismutase 1 (SOD1) protein have been linked to another neurodegenerative disease that affects motility (familial amyotrophic lateral sclerosis) (Huai and Zhang, 2019)
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However, excessive deposition can initiate the loss of tissue architecture, which may ultimately result in organ dysfunction and failure ( Indeed, age is associated with reduced acini, ductal dilation, fatty infiltration and fibrosis ( The pathogenicity of immune cells, either directly or indirectly involved in SG fibrosis, remains incompletely understood, while recent evidence has begun to shed light on the contributions of various immune cell populations to SG fibrosis
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