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In an in vitro study of resistance, a Luria – Delbrück fluctuation analysis was applied to generate two models of resistance propagated from single-cells, derived from PDCLs (WM989, WM983B): the first resistance condition was represented by a genetic “mutation”, heritable model, which harbors intrinsic capability to tolerate acute doses of vemurafenib (at 1μM)
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Vitamin E is a primary fat-soluble antioxidant that protects cell membranes from oxidative damage
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