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Even though the transfer of in vitro activated and engineered T-cells in non-conditioned recipients remains challenging, engraftment of extremely low T-cell numbers, as low as a single naïve T-cell, can already be sufficient to develop into highly effective effector and memory T-cell subsets in non-lymphodepleted hosts (136)

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For instance, exosome-like nanoparticles derived from Atractylodes lancea and Panax ginseng were shown to reduce melanin content by downregulating these melanogenic enzymes [37,38]