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Roles of ADDLs and tau in spine and dendrite instability in Alzheimer’s disease Extensive synapse loss and dendrite arbor atrophy is observed in Alzheimer’s disease 168–171 , and the reductions in synapse number strongly correlate with the magnitude of cognitive and memory impairment 172,173
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Changes in spine morphology and numbers are proposed to be mechanisms for converting short-term synaptic changes into highly stable and long-lasting changes (Hering and Sheng 2001)
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