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The DAO enzyme is produced in the villi lining the small intestines and is released to metabolize histamine.[ref] Histamine methyltransferase (HNMT) enzyme: The HNMT enzyme works throughout the body, including in the brain, to deactivate and break down histamine created by your cells .[ref] Too much histamine can result in allergy-like symptoms, including the histamine intolerance symptoms listed above

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Paired t-test analysis was used for before-and-after comparisons of continuous data