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PAO induced by spermidine (Spd) mediates the elevation of H 2 O 2 level, thereby activating the antioxidant system to eliminate excess ROS accumulation and relieve membrane lipid peroxidative damage and growth inhibition under saline-alkali stress (Yang J
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However, in the non-senescent control fibroblast model cultured in 10% FBS DMEM treated with or without FOXO4-DRI (25 ฮผM), no SA-ฮฒ-gal-positive cells were observed both in keloid fibroblasts and in normal skin fibroblasts (Supplementary Fig
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