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The complex molecular pharmacology of the dopamine D2 receptor: implications for pramipexole, ropinirole, and rotigotine
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However, factors such as chronic nutrient excess, physical inactivity, genetic predisposition, and aging can drive AT dysfunction, overwhelming its adaptive capacity ( Multiple mechanisms underlie AT dysfunction, including mitochondrial impairment, ER stress, inflammatory pathway activation, and extracellular matrix (ECM) remodeling
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