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(Nature, 2004) reported that Tβ4 improves cardiomyocyte survival and post-infarction cardiac function in murine models, with an anti-fibrotic effect
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226 Cu deficiency can also alter the expression of myocardial gene profile, for example by upregulating the inflammatory cytokine TNF-α and genes involved in regulating cardiac contractility, fibrosis, and calcium cycling, all of which may underlie the changes in cardiac function under Cu-deficient conditions
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