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This gradient exists since concentrations of glucose in plasma and CSF are approximately 5 mM (Psychogios et al., 2011) and 3 mM (Wishart et al., 2008) respectively, with a CSF:plasma glucose ratio typically being approximately 0.4–0.8 (Leen et al., 2012)

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It has been postulated that early-onset obesity carries favourable adipose distribution, conferring a metabolically healthier phenotype than if obesity develops in older adults [20]