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In hypertensive states, mitochondria generate excessive ROS due to electron transport chain (ETC) disruption, particularly at complexes I and III, coupled with reduced antioxidant defenses (e.g., Mn-SOD) (Grossini et al., 2025)
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Studies in our laboratory showed that glutamine supplementation (for 21 days) reduced the plasma concentrations of creatine kinase (CK) and lactate dehydrogenase (LDH)—markers of muscle damage—in rats submitted to strenuous resistance training [17,18]
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