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These results clearly indicate that the observed induction of c-Ret phosphorylation by hHGF and aML5-PEG3 relies on Met phosphorylation, although we are not certain which factor(s) present in FBS plays a role in this transactivation event
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It’s also worth noting that Novo Nordisk isn’t the only company interested in amylin-based approaches—Roche and Zealand Pharma are developing a separate amylin analog called petrelintide, underscoring the broader industry interest in this pathway
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