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The tomato DFR gene was used for two-stage editing in order to develop the technology of inserting a transgene into a given region of the genome
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Notably, aging-associated microglial dysfunction involves heme oxygenase-1 upregulation, which suppresses GPX4 expression and promotes iron accumulation, driving M1 polarization and neurotoxic cytokine production (IL-1β, TNF-α, NLRP3, caspase-1) (266)
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