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Prior to oocyte release, granulosa cells become luteinised by upregulating LHR expression, responding to human chorionic gonadotropin (hCG), and producing progesterone thus forming the corpus luteum in the secretory phase of the menstrual cycle

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A recent meta-analysis found treatment with metformin to be significantly associated with an increased incidence of vitamin B12 deficiency and reduced serum levels.8 It is therefore possible that the etiology in this case may have been twofold