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Targeted dietary supplements such as vitamin D [112,113], methylfolate [114,115], and carnitine [116,117], vitamin B 12 and other micronutrient supplementation [51,118], mitochondrial support, or supplements thought to be relevant to a child’s functional genomic situation

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This pathway first produces oxylipin epoxides and then diols from linoleic acid (LA, C18:2 n-6), alpha-linolenic acid (ALA, C18:3 n-3), arachidonic acid (AA, C20:4 n-6), eicosapentaenoic acid (EPA, C20:5 n-3) and docosahexaenoic acid (DHA, C22:6 n-3) ( FIGURE 1 Dimethyl sulfoxide has been shown to attenuate the accumulation of lipids in the liver as well as free fatty acid-induced cellular lipotoxicity ( Materials and Methods Animals Care and treatment of animals were in accordance with guidelines from and approved by the University of California, Riverside Institutional Animal Care and Use Committee (AUP #20140014)